The South Fork of the Spring River is a tributary of the Spring River, roughly 75 mi (121 km) long, in southern Missouri and northern Arkansas. The river flows through the Salem Plateau of the Ozarks and it is part of the Spring River Tributaries Watershed.
The South Fork rises in Howell County northeast of the unincorporated community of South Fork, Missouri and southwest of West Plains. The river flows generally southeast from Howell County through Fulton County before joining with the Spring River in Sharp County outside of Hardy.
It flows through eastern Ozark hill country, pasture land, and oak-hickory forests. It is a gravel bottom stream with some silty areas that contains a good smallmouth bass and shadow bass population. Catfish are also stocked annually.